PPIG and COVID-19: This combination therapy contains a CYP inhibitor, which substantially increases the risk of drug‐drug interaction in the elderly (>70) and the heavily medicated population.[38] The antiviral drug remdesivir has demonstrated only modest clinical efficacy, with the most significant impact observed in severely ill patients.[39, 40] Finally, despite the effectiveness of various COVID‐19 vaccines, due to the likelihood of RNA viral mutations, it is doubtful that any current vaccine will be effective against all new strains or future coronavirus outbreaks.