Rare cells expressing FB-like (I-cluster 12, Pi16+, Igfbp4+, and Dpep1+) or MΦ-like genes (I-cluster 14, Lgals3+, Cd68+, and Ptprc+) had low expression of the eYFP lineage label (see Supplementary material online, Figure S3), suggesting that these cells were not derived from VSMCs, similar to what has been proposed in atherosclerosis.29 The gene discussed is PI16; the disease is atherosclerosis.