In addition, administrating mice with antioxidants, either NAC or mitoquinone (MitoQ), rescued alcohol-induced hepatic steatosis and liver injury and improved alcohol-led hepatic FBXW7 up-regulation and the loss of IRF1 and NMNAT1 expressions, along with the restoration of nuclear NAD+ levels and NAD+/NADH ratio (fig. The gene discussed is IRF1; the disease is fatty liver disease.