Redox potential-triggered cGAMP release activated the STING pathway to generate several immune effector factors, such as IFN-γ–secreting CD8+ T cells (IFN-γ+CD8+ T cells), cytokines, etc., while the siPDL1 knocked down PD-L1 expression on the cancer cells, and the photosensitizer allowed the use of tumor photodynamic therapy (PDT) to induce ICD of the cancer cells. This evidence concerns the gene CD8A and neoplasm.