Redox potential-triggered cGAMP release activated the STING pathway to generate several immune effector factors, such as IFN-γ–secreting CD8+ T cells (IFN-γ+CD8+ T cells), cytokines, etc., while the siPDL1 knocked down PD-L1 expression on the cancer cells, and the photosensitizer allowed the use of tumor photodynamic therapy (PDT) to induce ICD of the cancer cells. Here, IFNG is linked to neoplasm.