The cytotoxicity induced by TriBAFF/CD3/ABDCon and BAFF CAR-T cells was assessed in vitro, and significantly greater toxicity to various cell lines, including ALL, CLL, MCL, Burkitt lymphoma, and MM cell lines, was observed after TriBAFF/CD3/ABDCon treatment (Fig. S16C). This evidence concerns the gene TNFSF13B and acute lymphoblastic leukemia.