Cytokine levels decreased for 6 of 9 assayed cytokines or the chemokine in the Chr7x3 AAB variant (IL-17a, IL-22, IL-5, IFN-γ, TNF-α, and IL-1β) and further decreased for all cytokines and the CXCL1 chemokine in the Chr7x3 ABB variant when compared to infection with Chr7x2 SC5314 (S3 Fig). The gene discussed is IL1B; the disease is infection.