CREB1 and colorectal carcinoma: Other studies revealed that the elevated fatigue levels in CRC patients were associated with the upregulation of B lymphocytes and CD8-positive T lymphocytes, as well as increased transcription factors involved in lymphocyte activation and inflammation (NF-κB, STAT, CREB/ATF, TNF-R1, and IL-6), but reduced activity of interferon regulatory factors (IRFs) [21,62].