In a sample of 89 Hispanic/Latino patients with CRC, elevated fatigue levels were linked with the upregulation of B lymphocytes and CD8-positive T lymphocytes, alongside increased transcription factors involved in immune activation, such as nuclear factor κB (NF-κB), signal transducer, and activator of transcription (STAT) [21]. The gene discussed is NFKB1; the disease is colorectal carcinoma.