RELN and epilepsy: Autosomal dominant families with lateral TLE or epilepsy with auditory features have been described, with pathogenic variants in LGI1 and RELN genes found in 50% of these families.8,25,26 Previous studies have indicated that most monogenic causes of lateral TLE are associated with familial cases, and pathogenic variants in LGI1 are identified in less than 5% of sporadic lateral TLE cases.25-27 Within our cohort, only one twin pair had familial lateral TLE, while the other four pairs had sporadic lateral TLE.