Another cytokine augmented by iTcES treatment is IL-31, which stimulates the proliferation of hematopoietic progenitors in the bone marrow and spleen (Broxmeyer et al. 2007); however, it remains unknown whether iTcES-induced IL-31 may favor hematopoietic progenitors that contribute to colonic epithelial cell replenishment in colitis. This evidence concerns the gene IL31 and colitis.