TLR4 and Familial prostate cancer: Dysbiosis in the gut microbiota had been shown to promote the progression of prostate cancer in antibiotic exposure mice via the Toll-like receptor 4 (TLR4) activated transcription factor-κB (NF-κB)—interleukin (IL)−6- signal transducer and activator of transcription 3 (STAT3) axis [12].