Furthermore, AML with t(8;21) frequently harbors mutations in KIT that lead to constitutive KIT activation, mediate activation of downstream signaling pathways involved in cell proliferation, differentiation, and survival, including the PI3K, JAK/STAT, MAPK, and Src kinase pathways, ultimately associating in some studies with inferior relapse free survival and overall survival (OS) [3–5]. This evidence concerns the gene KIT and acute myeloid leukemia.