S100A8 and infection: In line with the results described above, DEGs unique to the SA group at 3 DPI were enriched in skin barrier repair (KRT1 and LCE2C) and immune activation (IL1A and IGHM), while those unique to the infection condition enriched in inflammatory processes (SERPINE1 and CD55) and immune responses (S100A8 and SERPINE1) (Fig. 2A and B).