Interestingly, in the TIME of melanoma, inhibition of HIF-1α transcriptional activity led to the infiltration of NK cells and CD8+ T cells, which was associated with elevated release of the chemokines CCL2 and CCL5.33 Another notable butyrate-dependent chemokine identified by Olink-seq is MCP-3, which plays a crucial role in regulating NK cells behavior, including their migration and chemotaxis.34 Moreover, RNA-seq identified CX3CL1 as an adhesion molecule (Figure 4(c)). This evidence concerns the gene HIF1A and melanoma.