HDAC9 and neoplasm: Prior studies suggest that the anti-tumor and anti-inflammatory effects of butyrate may result from HDAC inhibition, which suppresses cell proliferation and differentiation.36 Moreover, active enhancers regulate gene expression by interacting with their target promoters.37 However, in our study, through integrated genomic analyses, we systematically examined how the enhancer landscape interact with the rapid transcriptional burst typical of hepatic tumor cells under butyrate treatment.