As is well known, SLC25A22, as a mitochondrial glutamate transporter, plays a critical role in mitochondrial energy metabolism involving glutamine and in the production of GSH.[23] Previous studies have shown that SLC25A22 contributes to tumorigenesis in colorectal cancer by modulating associated energy metabolism and signaling pathway.[24] To investigate its role in the biological behavior of CSCC, we developed MS751 cell lines with either knockdown or overexpression of SLC25A22. The gene discussed is SLC25A22; the disease is colorectal cancer.