These tissue-specific promoters include promoter PI.1 (primarily expressed in placenta), PI.3 (expressed in adipose tissue and mammary glands), PI.4 (extragonadal sites, such as the main promoter in adipose tissue), and P2 (expressed in adipose tissue, breast cancer, ovarian cancer, endometrial cancer, containing cAMP response elements). The gene discussed is SERPINA1; the disease is breast carcinoma.