Chen et al. demonstrated that curcumin-loaded liposomal nanostructures significantly inhibited B16BL6 melanoma cell growth [136], due to improved drug distribution and PI3K/AKT pathway blockade, offering potential for skin cancer treatment [137].In recent years, the combination of liposome nanocarriers for curcumin delivery and blue light diode-mediated photodynamic therapy has achieved ideal biological activity and anti-cancer function. Here, AKT1 is linked to cancer.