,101 This suggests the robust chemotactic exerted by Fgf8. 103Fgf8 drives nephrogenesis independently of Spry1, Fgf9 and Fgf20. In mice, simultaneous deletion of both Fgf8 and Fgf20 leads to renal agenesis, impaired proliferation of nephron progenitors, and cell death. This evidence concerns the gene FGF8 and renal agenesis.