,101 This suggests the robust chemotactic exerted by Fgf8. 103Fgf8 drives nephrogenesis independently of Spry1, Fgf9 and Fgf20. In mice, simultaneous deletion of both Fgf8 and Fgf20 leads to renal agenesis, impaired proliferation of nephron progenitors, and cell death. The gene discussed is FGF20; the disease is renal agenesis.