Importantly, ARV p17 protein functions as a negative regulator of TKs5-Nck1 and TKs5-Rab40b complexes by activating the p53-PTEN pathway and by suppressing FAK-Src and Rab40b-PI3K-Akt pathways, which inhibits invadopodia formation in HeLa and A549 cancer cells. Here, PTK2 is linked to cancer.