DNMT1 and Familial prostate cancer: Similarly, complex 11, also displayed a diverse array of binding targets, notably with DNMT-1, PARP-1, and the strongest binding affinity observed for the Alpha-Beta-tubulin dimer (1JFF) which could also account for strong in vitro anti-proliferative effects against colon and prostate cancer with IC50S of 0.63 μM and 0.22 μM respectively (Adokoh et al., 2017).