NUAK1 and breast cancer: The DNA-binding protein chromodomain helicase DNA binding protein 1 like (CHD1L) is overexpressed in various solid tumors and promotes tumor progression in colorectal cancer by facilitating G1/S phase transition and inhibiting apoptosis [65], while in breast cancer, it promotes tumor invasion and metastasis through the PI3K/Akt/ARK5/mTOR/MMP pathway [66].