While TGF-β and TNF-α were chosen for their well-established relevance in liver fibrosis and therapeutic potential, it is important to acknowledge that other pathways, such as platelet-derived growth factor (PDGF), mitogen-activated protein kinase (MAPK), mitogen-activated protein kinase/ERK kinase (MEK), mammalian target of rapamycin (mTOR), and protein kinase B (AKT), are also critical in the fibrogenic process. The gene discussed is TNF; the disease is Hepatic fibrosis.