TNF and acute monocytic leukemia: To characterizethe anti-inflammatory effect of the CBP/EP300-BRD inhibitors 2 and 5, we explored their effect on the TNF-αresponse in THP-1, a human acute monocytic leukemia cell line commonlyused to study monocyte and macrophage functions. Firstly, we validated that stimulation of these cells with10 ng/mL TNF-α (dose response in Figure S2) increased the expression of several pro-inflammatory cytokines(Figures a and S3).