MAPK3 and neoplasm: For example, by regulating the Phosphoinositide 3-Kinase (PI3K)/Protein Kinase B (Akt)/Mammalian Target of Rapamycin (mTOR), Wnt/-catenin, and Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) pathways, quercetin could promote the loss of cell viability, apoptosis and autophagy and then exert anti-tumor effect (15).