It results from mutations in the RyR2 gene, causing spontaneous calcium release from the sarcoplasmic reticulum in cardiac cells. Proper anesthetic management for patients with CPVT requires an understanding of potential risks and careful planning, avoiding factors that might increase catecholamine levels during the perioperative period. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.