The patient refused to undergo pelvic lymph node aspiration biopsy and PET-CT, and the final diagnosis was “chronic lymphocytic leukemia (CLL) with prostate involvement (Rai II stage, Binet B stage, TP53 mutation, IGHV unmutated, very high risk of CLL-IPI), prostate follicular adenocarcinoma (cT2bNxM0), and hepatocellular carcinoma after treatment. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.