The markers CD151, CD171, and TSPAN8 were the most effective in differentiating cancer patients of all histological subtypes from those without cancer, with CD151 showing AUC of 0.68 (p = 0.0002), CD171 showing AUC of 0.60 (p = 0.0002) and TSPAN8 showing AUC of 0.60 (p = 0.0002). The gene discussed is TSPAN8; the disease is cancer.