CD5L, CLEC3B, ITIH4, SERFINF1, SAA4, SERFINC1 and C20ORF3 were all expressed at high levels in exosomes derived from lung cancer patients, with AUC > 0.750. Among these, CD5L exhibited the highest AUC of 0.943. This evidence concerns the gene CLEC3B and lung carcinoma.