One study identified twelve proteins, such as members of the annexin family (annexin A1, A2, A3, A5, A6, A11), along with PR-OM1, MUC1, BPIFA1, CRNN, MUC5B and IQGAP, which showed significant differences between lung cancer patients and healthy individuals. This evidence concerns the gene BPIFA1 and lung carcinoma.