Since its initial identification in a CNS tumor in 2016, the EWSR1::PATZ1 fusion has been reported across diverse primary CNS tumors, including NEpT, ependymoma, ganglioglioma, pleomorphic xanthoastrocytoma, low-grade glial/glioneuronal tumors, astroblastoma and glioblastoma (5). Here, PATZ1 is linked to ganglioglioma.