While this study establishes the functional benefit of GLUT5 armouring in enhancing CAR T-cell activity under glucose-limiting conditions, future work will investigate the phenotypic and metabolic state of tumour-infiltrating CAR T cells, including markers of exhaustion (e.g. PD-1, TIM-3) and stemness (e.g. TCF-1). Here, SLC2A5 is linked to neoplasm.