Understanding the mechanisms of maintaining high p-tau levels without triggering aggregation or pathology during foetal development could offer valuable insights for Alzheimer’s disease and other tauopathies.35 The natural protective mechanisms in newborns may be mimicked as therapeutic approaches aiming at modulating tau phosphorylation, improving tau clearance and preventing pathological tau aggregation in neurodegenerative diseases. This evidence concerns the gene MAPT and neurodegenerative disease.