These findings build upon a previous publication that examined the relationship between Alzheimer’s disease biomarkers and neonatal hypoxia, where we reported that cord blood BD-tau is associated with indicators of foetal hypoxia, while p-tau217 levels may reflect a more general susceptibility to neurodevelopmental issues.29 In the present study, we contextualize these associations within biomarker changes observed in older individuals and Alzheimer’s disease. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.