The Parkinson’s disease and Alzheimer’s disease pathways in the SncaG51D/G51D cortex were significant due to down-regulation of proteins involved in oxidative phosphorylation (NDUFAB1, COX5A, NDUFB8), and in the case of PD dopamine transport (SLC18A2). This evidence concerns the gene COX5A and early-onset autosomal dominant Alzheimer disease.