The genes determined to be most closely related to tumor immunotherapy efficacy in at least three algorithms were ABCA7, ACTB, ACTG1, C12orf57, EEF1A1, HOOK2, JUNB, MAT2A, NR4A1, RHOB, SEMA4B and VMP1 (Supplementary Figure S1F), and they were considered the hub genes comprising Hub-EGFR.Sig (Figure 6A). This evidence concerns the gene HOOK2 and neoplasm.