CSF3 and graft versus host disease: Although G-CSF mobilization promotes a shift in T-cell polarization toward a more tolerogenic immune profile—potentially mitigating acute GvHD (32, 33), —it does not fully prevent it and has been associated with a higher incidence of chronic GvHD compared to unmanipulated DLI (34–39), likely reflecting distinct mechanisms underlying acute versus chronic disease pathogenesis.