FEJ also regulated the NF-κB signaling pathway, including Edaradd, Card10 and Atm. Edaradd knockdown in tongue squamous cell carcinoma (TSCC) cells reduces proliferation and induces apoptosis (94), while Atm deficiency disrupts hematopoiesis and reduces myeloid and lymphoid hematopoietic cells in zebrafish (95, 96). This evidence concerns the gene ATM and tongue squamous cell carcinoma.