Herein, our work detailed that SFRP2+ fibroblasts contribute to local immune inflammation of OLP within a transition into pro-inflammatory state directly, and promote the local immune network indirectly via crosstalk among CD8+ T cells and epithelial cells, which helps to reveal the potential function of heterogeneous fibroblasts in OLP and better understand unique cellular contributors involved in OLP pathological mechanisms. This evidence concerns the gene CD8A and oral lichen planus.