TNF and neoplasm: The dual signalling offered by the CD3ζ-TIR intracellular domain augments the secretion levels of IL-6, IL-12, IL-23, and TNF-α pro-inflammatory cytokines and ensures antigen-dependent antitumour activity, reflected by a robust phagocytic capacity, TNF-α dependent clearance of apoptotic tumour bodies, and emendation of the TME.