Another notable complex structural variant, called DUP4, creates a GYPB-GYPA fusion gene that alters the surface properties of RBCs and generates a hybrid glycophorin variant, called Dantu, making them less susceptible to P. falciparum invasion (Anstee, 2010; Leffler et al., 2017; Jaskiewicz et al., 2019) and confers a reduced risk of severe malaria (Louzada et al., 2020). Here, GYPB is linked to malaria.