Hypoxic conditions known to affect pulp homeostasis (Colombo et al. 2020) also promote pain in conditions such as sickle cell disease (Aich et al. 2019); several mechanisms such as sensitization of nociceptive TRPV1 receptors (Ristoiu et al. 2011) or algogenic action of Hypoxia Induced Factor 1‐alpha (HIF1a) can be hypothesized (Kanngiesser et al. 2014). This evidence concerns the gene HIF1A and sickle cell disease.