IGF1 and obesity due to melanocortin 4 receptor deficiency: In fact, although a direct correlation between growth hormone and serum total IGF‐1 concentrations was observed during exercise across all participants (Figure 4b), this correlation was not significant within the subgroups of participants with and without obesity (Figure 4d,f), suggesting the possibility of distinct mechanisms regulating serum total IGF‐1 concentrations during exercise within each group.