S1PR5 and cancer: Besides as a co‐inhibitory marker, KLRG1 could be also a “senescent” marker or “exhaustion” markers for T cells.[49, 50, 51, 52] S100A4 is potentially associated with angiogenesis and cancer metastasis.[53, 54, 55] CX3CR1 is expressed in inflammatory response in T cells and NK etc.,[56] and it is associated with the metabotropic function and modulating cell activity toward higher active state.[57] S1PR5 is a migratory receptor with an uncharted function in T cells.