As shown in Table 1, highly expressed genes in cluster 3 (B cells) or cluster 8 (B cells) included CD22, CD79b, and EIF2AK3, etc. CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.[38] CD79b and CD24a can function in activating B cells. This evidence concerns the gene CD22 and autoimmune disease.