CEACAM 1, 5, and 6 werepreviously described as important cell adhesion molecules and as promisingbiomarkers in melanoma, lung, colorectal, and pancreatic cancers.−,  Furthermore, the minichromosome maintenance complex components MCM3,MCM4, and MCM6 showed clear protein abundance patterns based on theradiation response (Figure F) and have already been described in colorectal cancer progression.−, The gene discussed is MCM4; the disease is melanoma.