The autophagic activity-related and DNA damagerepair proteins TOM1, CAPNS1, TP53BP1, HS1BP3, as well as COTL1 andDCPS, discriminated non- and nearly complete from complete responders.In the tumor-surrounding tissue of nonresponders, the innate immuneresponse-suppressing protein CD55 was found specifically up-regulated.These proteins may serve as prognostic markers and potential therapeutictargets, requiring further validation in prospective studies. The gene discussed is COTL1; the disease is neoplasm.