CLCA1 and colorectal cancer: While RCN3 has already been described to playan important role in human colorectal cancer, FTL and PCOLCE were associated with poor prognosis in various cancertypes.−, ,  Interestingly, latent-transforming growth factor beta-binding protein2 (LTBP2), which was found to be significantly up-regulated in tumortissue samples, has already been identified in cancer-associated fibroblastsby proteome profiling and serves as a prognostic factor in colorectalcancer. Chloride channel accessory 1(CLCA1) was found to be significantly enriched in control tissue samplesof colorectal cancer patients.