The up-regulation of complement-associatedproteins like complement component C8 alpha and beta chain (C8A andC8B) in the tumor tissue of responders but not in the tumor tissueof nonresponders might result from the higher levels of CD55 in thestroma of nonresponders, thereby inhibiting the central driver ofthe complement cascade, C3 convertase. The gene discussed is CD55; the disease is neoplasm.