CALCA and Paget disease: The basic peptide hormone calcitonin has been clinically used for more than 40 years in the form of salmon calcitonin to control severe hypercalcemia and for metabolic bone diseases such as Paget’s disease and osteoporosis and is currently available in the pharmaceutical market as a nasal spray and intravenous, subcutaneous, and intramuscular injectable preparations [4,136,137].