This time, the effects were remarkable, achieving deep tissue penetration, leading to immediate cell death, tumor volume reduction, and ultimately eradication of subcutaneous xenograft formations in A431 (HER1 positive) and 3T3/HER2 (HER1 negative) tumor models in mice after a single dose of NIR, without cytotoxicity to the surrounding healthy tissue. The gene discussed is EGFR; the disease is neoplasm.