IL2 and neoplasm: The interaction between VSIG-3 from tumor cells and VISTA from T cells activates an unfavorable regulatory pathway, leading to a reduction in T cell proliferation and immune cell infiltration, as well as an increase in the production of proinflammatory cytokines and chemokines, including IL-2, IL-17, and IFN-γ [223,245,268,270,271,272].