According to standard 2D cell culture, GBM cell lines (U87 and U251) were treated for 72 h with increasing concentrations (0.1-1-10-100 μM) of SI306 and SI306-PD2 in the presence of DMEM medium with or without 10% FBS (FBS-DMEM and FBS-free DMEM). This evidence concerns the gene PAF1 and glioblastoma.