In addition, a nanoparticulate liposomal mRNA vaccine with sequences encoding for four class I MHC-restricted TAAs, with tetanus toxoid epitopes and targeting signal sequences intended for reaching immature dendritic cells in the lymphoid tissue, in combination with ICIs therapy in patients with resected and unresected advanced melanoma demonstrated a more effective CD4+ T cell-dominant responses, tumor killing, and a longer tumor-specific memory T-cell formation [31]. This evidence concerns the gene CD4 and neoplasm.