PSMB8 and melanoma: Evidence has reported that Trichostatin A (TSA, a HDACi targeting Class I and Class II HDACs: HDAC1-10) can significantly upregulate the expression of TAP2 (Transporter Associated with Antigen Processing 2), LMP2 (Low Molecular Weight Protein 2), LMP7 (Low Molecular Weight Protein 7), and Tapasin in melanoma cell lines (B16F10 cells) [45].