In clinical translation research, sequential treatment strategies combining HDACi with DC vaccines (pretreatment of tumor microenvironment with HDACi followed by DC vaccine inoculation) have demonstrated significant synergistic anti-tumor effects in melanoma, pancreatic cancer, and non-small-cell lung cancer models, not only enhancing CD8+T cell infiltration and activity but also reducing the proportion of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment [27]. Here, CD8A is linked to neoplasm.