For instance, syringic acid alleviates C. acnes-induced inflammation by activating Nrf2 and suppressing ROS accumulation [7], while gentiopicroside reduces ROS levels in TNF-α/IFN-γ-stimulated keratinocytes by regulating the Keap1–Nrf2 axis in an atopic dermatitis model [29]. The gene discussed is TNF; the disease is atopic eczema.