RIGI and infection: Studies examining the in vitro kinetics of Rift Valley Fever phlebovirus (RVFV) viral RNA accumulation indicated that the S segment ag-RNA is packaged into RVFV particles and transcribed to synthesize NSs mRNA immediately following infection, resulting in the expression of NSs at the early stages of infection [37], which could possibly lead to more efficient viral replication by interfering with RIG-I recognition [38].