Similar to what was reported for the SARS-CoV-2 infection, CCoV induced ERK1/2 phosphorylation only in the early stages of infection, up to the end of adsorption (1 h p.i.); during the rest of the viral replication cycle, phosphorylation levels remained similar to those of the uninfected controls (Figure 8). Here, MAPK3 is linked to infection.