Using binary logistic regression, we confirmed a low probability of COVID-19 developing in carriers of the mutational A-allele of the FGB gene within the codominant, dominant, superdominant, and additive models of pathology inheritance, and we also recorded an increased risk of COVID-19 in carriers of the G-allele (especially the GG genotype) of the FGB gene (rs1800790), with a protective role of the A-allele and AG genotype, respectively. The gene discussed is FGB; the disease is COVID-19.